Fresh Insights Help Unlock Mysteries of the First Stages of Life

08 Oct 2018

Key insights into how sperm and egg cells are formed have been discovered by the University of Edinburgh scientists, shedding light on the earliest stages of their development. Scientists carried out studies with mice to investigate the first stages of germ cell formation. 

This research shows for the first time how molecules influence the fate of the cells that define the DNA profile of future generations, experts say.

The findings focus on the development of germ cells – which turn into sperm and eggs. During reproduction, these germ cells join with one from the opposite sex to form a new individual.

Professor Ian Chambers from the University of Edinburgh’s MRC Centre for Regenerative Medicine, who led the study, said: Until now, studies of germ cell identity have focused on activity much later down the chain of events. 

“We can now begin to see the early events occurring as cells commit to germ cell development. These exciting findings open the door towards a better understanding of the processes governing the very earliest stages in the separation of germ cells from all other cells.”

University of Edinburgh’s scientists focused on a molecule known as BMP4 and found that it blocks the activity of Otx2, a gene regulator that directs the development of non-germ cells, known as somatic cells.

The scientists showed that blocking Otx2’s activity by BMP4 is crucial to the development of germ cells.

The study is published in Nature and was funded by the Medical Research Council (MRC) and the Biotechnology and Biological Sciences Research Council.

The University of Edinburgh are collaborative partners of Zhejiang University in the establishment and running of the ZJE Institute.