Epigenetic editing and therapeutic approaches to autism
Date and Time :
22 November 2022, 10:00-11:00pm
Room A203-1, ZJE building
Zoom:833 0831 3045
Prof. Rudolf Jaenisch
Founding Member, Whitehead Institute
Professor of Biology, MIT, Department of Biology
Host: Dr. Di Chen
Jaenisch, a Whitehead Founding Member, focuses on understanding epigenetic regulation of gene expression. He is a pioneer in the study of cellular reprogramming, the process of converting adult cells into induced pluripotent stem (iPS) cells.
Jaenisch’s lab was the first to create a transgenic animal model using SV40 and retroviruses. He has been the first to conduct an experiment showing that therapeutic cloning could correct genetic defects in mice. He is currently using patient-derived iPS cells to develop sophisticated models for the study of cancer, diabetes, and neurodegenerative disorders, including Alzheimer's disease and Parkinson's disease. Jaenisch is working with human stem cells to study disease risk factors.
Jaenisch’s discoveries forever changed the landscape of how biological science is conducted. His methodological breakthroughs allow scientists, for the first time, to study human brain functions in normal and pathological conditions in its full complexity of all brain cell types. His stellar scientific acumen will be focused in partnership with Rick Young on condensate biology advancing research in cancer and neurodegenerative disease.