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2023年3月26日（周日）

浙江大学海宁国际校区

Breast Cancer Precision Medicine

Dr. Lim Yoon Pin

Ningbo Health and Industry Research Institute

Dr Lim was a professor at the National University of Singapore, founder and chief scientific officer of Oncotec, an in vitro diagnostics startup, before he was accorded the national high-level talent award by China. He joined the Ningbo health and industry research institute in Feb this year. 

Dr Lim owns 10 patents with 4 being licensed and/or commercialized. He published more than 60 peer reviewed papers and secured more than 10 million SGD as a PI and more than 30 million SGD as a co-PI. He is one of the global leaders in WBP2 oncogene research. He will share his scientific journey and findings of more than 10 years, starting from the discovery of a novel breast oncogene to its potential utility in early detection and precision medicine of cancer.

Date and Time: 22nd Mar. 2023

14:00-15:30 Academic Consultation

15:30-16:30 Room A203-1, ZJE building

Host: Ting Gang Chew

详细职位信息请见：

ZJE高层次人才招聘 | 国际化人文环境、多学科交叉平台等你加入

ZJE伙伴计划博士后招聘 | 国际化人文环境、多学科交叉平台等你加入

Chemical Biology of Biological Aggregates in Membraneless Organelles and the Stressed Proteome

Prof. Xin Zhang

School of Science, School of Life Sciences, Westlake Laboratory, Westlake University

Prof. Xin Zhang is the Professor of Chemistry and Cell Biology at the Westlake University, Hangzhou. Prior to joining the faculty at Westlake in 2021, Zhang was the Paul & Mildred Berg Early Career Professor and associate professor of chemistry and of biochemistry and molecular biology at the Pennsylvania State University. 

Prof. Zhang’s research is focused on the chemistry of biological aggregates formed by proteins and RNAs under physiological and pathological conditions. Zhang’s independent work has received multiple honors and awards, including Priestley Prize for undergraduate teaching in chemistry, Kavli Fellow of the National Academy of Sciences USA, CAPA Distinguished Junior Faculty Award, NSF CAREER award, NIGMS MIRA, Pew Scholar in the Biomedical Sciences, Scialog Fellowship, Sloan Research Fellowship, the Lloyd and Dottie Huck Early Career Award, the Burroughs Wellcome Fund Career Award at the Scientific Interface. 

Date and Time: 1st Mar. 2023

14:00-15:30 Academic Consultation

15:30-16:30 Room A203-1, ZJE building

Host:  Prof. Chaochen Wang

1.Talk title:

Nonadipogenic Role for Adipocyte Precursors

2.Speaker Name and Position and Institute:

Bo Shan (闪波)

Principal Investigator, Institute of Translational Medicine

Zhejiang University

3.Speaker introduction:

Dr. Bo Shan is a Principal Investigator at the Institute of Translational Medicine of Zhejiang University. The primary research focus of his group is to understand pathogenic mechanisms underlying metabolic diseases. Focusing on elucidating the mechanisms the mechanisms that elicit metabolic inflammation in adipose tissue and liver, his previous work has demonstrated the pathologic importance of metabolic tissue microenvironments as follows: 1) identifying the critical functions and underlying mechanisms of perivascular cells in initiating the formation of physiological and pathological microenvironment in adipose tissue; 2) illustrating the key role of macrophage ER homeostasis in regulating the pathological microenvironment in obese adipose tissue; 3) revealing the function of the ER stress sensor IRE1α in driving hepatic inflammation. The results of his work have been published in high-profile journals such as Cell Metabolism, Nature Metabolism, Nature Immunology, etc. Dr. Shan’s research is supported the National Natural Science Foundation and Ministry of Science and Technology of China.

4. Host

Prof Jian Liu

5. Date

2022/12/22 Wednesday 3：30pm-4:30pm

Building cell lineages in development and disease

Dr. Weike Pei

Westlake University

Dr. Weike Pei obtained his Ph.D. in Immunology at Heidelberg University in 2018. In graduate school, he worked with Dr. Hans-Reimer Rodewald on cell fate decision of hematopoietic stem cells. Following a one-year postdoctoral training at the German Cancer Research Center (DKFZ), he joined Dr. Vijay Kuchroo’s lab at Harvard Medical School/Brigham and Women’s Hospital as a Research Fellow, working on immune regulation and cancer immunotherapy. In 2022, Dr. Weike Pei joined Westlake University as an Assistant Professor at School of Life Sciences. His research is published in Nature, Cell Stem Cell, Nature Protocols, and other journals. Dr. Pei has received several awards including CRI Eugene V. Weissman Fellow, CRI Irvington Postdoctoral Fellowship and MIT Technology Review Innovators Under 35 (China).

Dr. Pei’s previous research was focused on the development and application of novel lineage tracing technologies for understanding cell fate decision. By integrating developmental biology, immunology, systems biology and synthetic biology, Pei lab is developing multi-dimensional single-cell lineage tracing technologies, which aims to study cell fate regulation at genetic, epigenetic, transcriptional, and spatial-temporal scales. Using novel single cell approaches, Pei lab is investigating the development and regeneration of the blood and immune system under physiological conditions and challenges such as cancer, infection and aging.

Date and Time: 7th Dec. 2022

14:00-15:30 Academic Consultation

15:30-16:30 Room A203-1, ZJE building

Host：Dr. Wanlu Liu

Mitochondria, autophagy, and neurodegeneration

Prof. Chao Tong

Life SciencesInstitute, Zhejiang University

Dr. Chao Tong’s major research interest is to dissect the molecular mechanisms underlying neurodegeneration diseases. Particularly, her lab is interested in how organelles such as mitochondria, autophagosomes, and lysosomes contribute to neuronal homeostasis. They aim to identify novel players and to define molecular pathways in neural maintenance by using Drosophila as a model system. They also applied these discoveries to the higher organisms. In this talk, she will introduce stories about Miga, a novel mitochondrial protein that is required for neuronal homeostasis. She will talk about how Miga regulates mitochondrial dynamics; how Miga functions as an ER-mitochondrial contact protein; and how Miga modulates autophagy processes. Dr. Chao Tong is supported by grants such as “The National Natural Science Foundation Outstanding Young Scholars Program” and “The National Natural Science Foundation, key program”. She serves as an associate editor of Science Bulletin and board member of Biophysical Society of China, membrane biology branch and mitochondrial biology branch.

Date and Time: 30th Nov. 2022

14:00-15:30 Academic Consultation

15:30-16:30 Meeting Room Online https://zju.webex.com/meet/zhihong

Host：Dr. Zhi Hong

Topic 

Epigenetic editing and therapeutic approaches to autism

Date and Time : 

22 November 2022, 10:00-11:00pm

Room A203-1, ZJE building 

Link:

Zoom:833 0831 3045

Passcode:aaaa1111

Speaker：

Prof. Rudolf Jaenisch

Founding Member, Whitehead Institute

Professor of Biology, MIT, Department of Biology

Host: Dr. Di Chen

Rudolf Jaenisch，美国科学院院士，麻省理工学院怀特黑德生物医学研究所教授，干细胞研究领域的权威人物，研究做出第一只转基因小鼠。他是怀特黑德研究所的创始人之一，曾经担任过国际干细胞学会的主席。其在一系列的领域做出了有影响的工作，包括基因敲除小鼠、表观遗传学研究、核移植、iPS等。

Jaenisch, a Whitehead Founding Member, focuses on understanding epigenetic regulation of gene expression. He is a pioneer in the study of cellular reprogramming, the process of converting adult cells into induced pluripotent stem (iPS) cells. 

Jaenisch’s lab was the first to create a transgenic animal model using SV40 and retroviruses. He has been the first to conduct an experiment showing that therapeutic cloning could correct genetic defects in mice. He is currently using patient-derived iPS cells to develop sophisticated models for the study of cancer, diabetes, and neurodegenerative disorders, including Alzheimer's disease and Parkinson's disease. Jaenisch is working with human stem cells to study disease risk factors. 

Jaenisch’s discoveries forever changed the landscape of how biological science is conducted. His methodological breakthroughs allow scientists, for the first time, to study human brain functions in normal and pathological conditions in its full complexity of all brain cell types. His stellar scientific acumen will be focused in partnership with Rick Young on condensate biology advancing research in cancer and neurodegenerative disease. 

Light sheet microscopy: push live imaging gently.

Dr. Min Guo

College of Optical Science and Engineering, ZJU

Dr. Min Guo is a tenure-track professor (100-Talent Investigator) at Zhejiang University. He received his Ph.D. degree in Instrument and Meter Engineering at Zhejiang University in 2016. He joined the National Institutes of Health as a Postdoc Fellow in 2016 and then as a Biomedical Scientist in 2019 before he returned to Zhejiang University in 2022. His research interests focus on high temporal-spatial resolution fluorescence microscopy including structured illumination microscopy, light sheet microscopy, and microscopic image analysis. He has developed several cutting-edge imaging techniques adopted in biomedical research by more than 20 labs across the world, and published ~ 20 papers in Journals such as Nature, Nature Biotechnology, Nature Methods etc. He also won the NIBIB’s Xiuwen Wang Memorial Award in 2019 and the Microscopy Today Innovation Award in 2020.

Date and Time: 16 Nov. 2022, 15:30-16:30

Room A203-1, ZJE building

Host：Dr. James Wang

Circular RNAs: subtypes, functions, and related mechanisms.

Prof. Ge Shan

School of Basic Medicine, University of Science and Technology of China (In transition). Run -Run Shaw Hospital, School of Medicine, Zhejiang University

Prof. Ge Shan have been focused on the study of noncoding RNAs for their regulatory roles in the flow of genetic information. His lab has identified new noncoding RNAs (e.g. MecciRNAs, EIciRNA, 5S-OT, ASAT siRNA, tiny RNA, p53R175H Aptamer RNA), and have revealed functions and novel functional mechanisms of these ncRNAs. Shan lab have explored methodologies of utilizing noncoding RNAs (e.g. p53R175H Aptamer RNA and human 5S-OT) to modulate the expression of genetic information. Dr. Ge Shan have published research articles as the senior corresponding author in journals such as Developmental Cell, Nature Structural & Molecular Biology, PNAS, Science Advances, and Nature Communications. These studies have been highlighted in Nature Reviews Molecular Cell Biology, Nature Reviews Genetics, Nature Reviews Microbiology, Science Editors’ Choice, etc. Dr. Ge Shan is supported by grants and professorship to top young Chinese scientists such as “The National Science Fund for Distinguished Young Scholars” and the National Leading Scientist of the “Ten Thousand Talent Program”.

Date and Time: 9 Nov. 2022, 15:30-16:30

Room A203-1, ZJE building

Host：Dr. Lingfeng Meng

ACT系列讲座之校友说|关于海外留学，你想知道的都在这里

时间Time：19:00-21:00

日期 Date：2022-11-8

地点Venue：线上

Talk title:

How is evolutionary principle useful for biomedical research

Speaker Name and Position and Institute:

Guojie Zhang 

Chair Professor, Evolutionary & Organismal Biology Research Center, School of Medicine, Zhejiang University

Adjunct Professor in University of Copenhagen and Kunming Institute of Zoology

Speaker introduction or talk content:

Professor Guojie Zhang is an expert in biodiversity genomics and ecological evolutionary genomics. He is currently a chair professor at Evolutionary & Organismal Biology Research Center of Zhejiang University, and an adjunct professor at the University of Copenhagen and the Kunming Institute of Zoology, Chinese Academy of Sciences. Before he joined Zhejiang University, he was also the youngest full professor at the University of Copenhagen. 

Professor Guojie Zhang has made outstanding academic contributions in the frontier field of biodiversity genomics and ecological evolutionary genomics. As of August 2019, more than 120 papers have been published in international high-impact academic journals, including 14 articles in Science, 8 articles in Nature, 6 articles in Nature Genetics, 1 article in Cell, and dozens of Nature research journals. He has successively served as a judge for many national foundations such as the United States, Canada, France, Switzerland, the United Kingdom, Denmark, Sweden, Israel, etc., and has served as a manuscript reviewer for many top international journals including Nature, Science, and Cell. He is also as editorial Board member of GigaScience, Human Heredity, Zoological Research and the Encyclopedia of Life Sciences.

Host:

Prof. Suhong Xu

Date:

2022/11/3 Thursday, 3:30pm-4:30pm

The late stage of autophagy

Prof. Yueguang Rong

School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology

In 2012, Prof. Yueguang Rong got his PhD training from Tsinghua University in Dr. Li Yu’s lab, and then did his postdoctoral research at UT Southwestern Medical Center in America with Dr. Qing Zhong (2012-2017). He moved back to Huazhong University of Science and Technology, and was appointed as the director of pathology department in 2018. He was supported by Overseas High-level Young Talents Project, the Major Research Plan and General Program of NSFC. His research works was published in Nature Cell Biology, Journal of Cell Biology, PNAS, Trends Cell Biology and Autophagy. His primary research interests focus on the late stage of autophagy including autophagic lysosome reformation (ALR), autophagosomal components recycling (ACR) and autophagosome-lysosome fusion and the related physiological/pathological functions. He dissected the spinster, clathrin and PI (4,5) P2 related mechanism for autophagic lysosome reformation (ALR). Recently, he discovered a novel cellular process and identified the ‘RECYCLER’ complex for ACR. 

Date and Time: 26 Oct. 2022, 15:30-16:30

Room A203-1, ZJE building

Host：Dr. Zhi Hong

Germinal center selection and neuronal regulation of humoral immunity

Prof. Hai Qi

Dean of School of Medicine Laboratory of Dynamic Immunobiology, Institute for Immunology Tsinghua University

Dr. Qi is a Professor in Immunology at Tsinghua University. He studies humoral immune regulation and germinal center biology. His work has made important contributions to our understanding of molecular mechanisms underlying T-B interactions, follicular helper T-cell development and function, and germinal center positive selection. His group has also made important advances in mechanistic understanding of how sexual dimorphism is orchestrated in B-cell immunity and how brain can directly control antibody responses. Dr. Qi is an HHMI International Scholar and has been recognized by numerous awards, including an AAI-BD Investigator Award.

Date and Time: 25 Oct.(Monday) 2022, 15:30-16:30

Room A203-1, ZJE building

Host: Prof. Wanlu Liu

Systems Virology and Immunology

Prof. Ren Sun

Chair professor and Director of Center for Infectious Disease Research.

School of Life Sciences, Westlake University.

Professor Ren Sun takes systems biology approaches to address critical interactions between virus and host. His lab has integrated genomics, proteomics, structural biology to characterize biological processes at both population and single virus/cell levels. His team has developed a method that can generate functional maps of entire viral genomes at single nucleotide resolution. It lays the foundation for comprehensively defining virus-host interactions, and enables engineering virus for rational vaccine design. The approach was demonstrated with influenza virus in vitro and in vivo: when the immune-evasion functions were systematically identified and removed from the viral genome, the engineered viruses became more immunogenic than the wild type, but severely attenuated in vivo. Thereby, it can be a general rational approach to develop therapeutic or prophylactic vaccine for many pathogens. His team is also developing high-throughput technology platforms to map epitope-specific antibody responses, to systematically define the immunome of hosts post infection or vaccination. These technology platforms will be also applied to studies on allergy, auto-immune diseases and neuroimmunology.

Date and Time: 12 Oct. 2022, 15:30-16:30

Room A203-1, ZJE building

Host：Dr. Liu Wanlu

Exploration of clinical application of biomaterials

Prof. Min ZHOU

Doctoral supervisor

Institute of Translational Medicine, Zhejiang University

Prof. Zhou is an outstanding scientist focusing on novel biomaterial development and the clinical application of biomedical materials. He has carried out in-depth and systematic research on the early diagnosis and precise treatment of major diseases such as malignant tumors and infectious diseases, and has achieved a series of innovative findings. He has published more than 100 papers in high-impact journals such as Nature Communications, Science Advances, and Advanced Materials, including 10 cover papers. The nanodrug developed in his group has been used in clinical trials, which has successfully cured many patients. In 2017 and 2018, Prof. Zhou won the "Top Ten Annual Academic Progress Nomination Award of Zhejiang University". His achievements have been widely reported by the media, such as Xinhua News Agency, People's Network, Guangming Network, Zhejiang Daily, Zhejiang Satellite TV and so on. His invention was considered as one of new technologies recommended in the drug delivery field in the Nature Medicine magazine.

Date and Time: 11 Oct. 2022, 14:00-14:50

Room A203-1, ZJE building

Host：Dr. Yuehai KE

Systems Virology and Immunology

Prof. Ren Sun

Chair professor and Director of Center for Infectious Disease Research.

School of Life Sciences, Westlake University.

Professor Ren Sun takes systems biology approaches to address critical interactions between virus and host. His lab has integrated genomics, proteomics, structural biology to characterize biological processes at both population and single virus/cell levels. His team has developed a method that can generate functional maps of entire viral genomes at single nucleotide resolution. It lays the foundation for comprehensively defining virus-host interactions, and enables engineering virus for rational vaccine design. The approach was demonstrated with influenza virus in vitro and in vivo: when the immune-evasion functions were systematically identified and removed from the viral genome, the engineered viruses became more immunogenic than the wild type, but severely attenuated in vivo. Thereby, it can be a general rational approach to develop therapeutic or prophylactic vaccine for many pathogens. His team is also developing high-throughput technology platforms to map epitope-specific antibody responses, to systematically define the immunome of hosts post infection or vaccination. These technology platforms will be also applied to studies on allergy, auto-immune diseases and neuroimmunology.

Date and Time: 12 Oct. 2022, 15:30-16:30

Room A203-1, ZJE building

Host：Dr. Liu Wanlu

The axolotl’s journey to the modern molecular era

Prof. JiFeng Fei

Doctoral supervisor

Guangdong Provincial People’s Hospital/ Guangdong Academy of Medical Sciences

Prof. JiFeng Fei is a Guangdong Pearl River Scholar Distinguished Professor, member of the Youth Committee and Developmental Biology Committee of the Chinese Society for Cell Biology. He has long been engaged in using animal organisms to generate disease models to study the mechanisms of central nervous system development and regeneration. In recent years, he mainly focused on a vertebrate model Mexican axolotls to elucidate its molecular and cellular mechanisms of tissue regeneration using functional genomics, single-cell sequencing, spatial transcriptomics, living-imaging and drug screening approaches, which may provide feasible strategies to improve limited regenerative capacity in mammals. He has published more than 20 research articles in peer reviewed journals, including Nature, Science, Nature Commun, Nature Protoc, PNAS, PLoS Biol and Cell Rep.

Date and Time: 28 Sept. 2022, 15:30-16:30

Room A203-1, ZJE building

Host：Dr. Wang Chaochen

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