Talk Title：Balanced Between Order and Disorder: A Prospering New Phase in Transcription Regulation

Speaker  ：Dr.Huasong Lu   

Speaker’s Position：Principal Investigator 

Institution：Life Sciences Institute, Zhejiang University

Speaker’s Introduction   

Dr. Huasong Lu is a Principal Investigator at the Life Sciences Institute of Zhejiang University. The primary research focus of his group is to understand the regulation of gene expression at the molecular level, with a particular interest in elucidating the mechanisms underlying transcriptional elongation control and how its deregulation leads to human diseases. The main achievements from his research are: (i) demonstrating the phase separation mechanism for Pol II CTD hyperphosphorylation and transcription elongation activation; (ii) providing evidence to elucidate the functional significance of Super Elongation Complex (SEC) in HIV transcription; (iii) developing novel inhibitor targeting CDK9 for cancer treatment. The results of his work have been published in high-profile journals such as Nature, Nature Cell Biology, PNAS, etc. Dr. Lu’s research is supported by the Excellent Young Scientists Fund Program and the National Natural Science Foundation of China. He also served as the referee for scientific journals, including Nature Structural & Molecular Biology, Nature Chemical Biology, Nuclear Acid Research, etc.

Date and Time

26th May 2023 (Wednesday)

15:30-16:30 Seminar, A203-1, ZJE Building

16:30-18:00 Academic Consultation

Host：CIIC – Prof. Jian Liu

Talk title: In Vitro Generation of Human Cardiac Tissue and Multiple-Organogenesis Model

Speaker introduction: 

Dr. Xiu-Jie Wang is a Principal Investigator at the Institute of Genetics and Development, Chinese Academy of Sciences, and the director of the Research Center for Molecular Systems Biology. She received her bachelor in Biology at Nankai University in 1998, her master degrees in biochemistry at Hong Kong University of Science and Technology in 2000, and earned her Ph.D. in bioinformatics from The Rockefeller University in 2004. Dr. Wang mainly engaged in bioinformatics and experimental biology researches related to non-coding RNAs and RNA modification, in recent years, her lab has also started researches on the generation of human multi-tissue embryo-like in vitro models and 3D printing-based cardiac tissue construction. Dr. Wang has published 113 SCI papers, with an H-index of 51. She received the Outstanding Young Scholar Research Fund from National Science Foundation of China in 2007, has won a few national wide awards and the 2022 3D Pioneers Challenge MEDTECH Award. 

Affiliation:

Principal Investigator

Institute of Genetics and Developmental Biology, Chinese Academy of Sciences

Date and Time: 17th May 2023 (Wednesday)

13:00-14:30 Academic Consultation

14:30-15:30 Seminar, A203-1, ZJE Building

Host: Prof. Di Chen

第十五期“爱浙谭”IZJEer Talk座谈会

时间：2023年5月5日（周五）晚17:00-18:00

地点：ZJE大楼A103

主题：与同学们交流对本科专业和教学的想法与建议

面向全体本科生

时间：2023年4月20日（周四）晚17:00-18:00

地点：ZJE大楼A123

标题：第十四期“爱浙谭”iZJEer Talk座谈会

面向全体本硕博群体

1.Talk title:

Precision Cancer Models for Investigating Tumorigenesis, Progression, and Treatment

2.Speaker Name and Position and Institute:

Prof. Chong Chen 

State Key Laboratory of Biotherapy, West China Hospital, Sichuan University

3.   Speaker introduction or talk content

Dr. Chong Chen got his BS degree from Peking University in 1999 and his Ph.D. from the University of Michigan-Ann Arbor in 2009. He had his postdoc training at Cold Spring Harbor Laboratory and Memorial Sloan Kettering Cancer Center before establishing his lab at Sichuan University in 2014. He received the National Natural Science Foundation of China Outstanding Youth Fund in 2015. The Chen laboratory’s researches focus on the molecular mechanisms of tumorigenesis with animal models. He identified new tumor suppressors such as KMT2C and PHF23. Recently, he studied metastasis and chemoresistance in lung cancer and bladder cancer. His group findings were published in the top journals, including Nature, Cancer Cell, Cancer Discovery, and Nature Cancer.

4.Date and Time: 11 April 2023

14:00-15:30 Academic Consultation

15:30-16:30 Seminar， A203-1 ZJE Building

Host: Dr. Jian Liu

Talk title:

Decoding the transcription circuitry when life begins

Prof.Wei Xie 

School of Life Sciences, Tsinghua University

HHMI International Research Scholar

Speaker introduction:

Dr.Xie received his B.S. degree in Molecular Biology at Peking University in China in 2003. He pursued his Ph.D study at UCLA, where he joined the laboratory of Michael Grunstein to study the function of histones and histone modifications. He also obtained a M.S. double degree in statistics at UCLA with Ker-Chau Li. After completing his graduate studies in 2008, he continued research in epigenetics and transcription regulation as a postdoctoral fellow in Bing Ren’s lab at the Ludwig Institute for Cancer Research, UCSD in 2009. After his postdoc training, he joined Tsinghua University, School of Life Sciences, in Beijing as a Principal Investigator in 2013. He is also a member of the Tsinghua-Peking Joint Center for Life Sciences. Using interdisciplinary approaches, Dr. Wei Xie is dedicated to understanding how the epigenome is inherited, reprogrammed, and established in early mammalian development when life just begins. His group established a series of ultra-sensitive technologies to analyze chromatin dynamics using a few hundred cells. He has authored over 80 publications, including those published in Nature, Science, Cell as the first-author/correspondence author. His work has been cited over 18,000 times. He has won numerous awards including Qiushi Excellent Young Scholar Award, Outstanding Young Scholar Award from National Science Foundation of China, C. C. Tan Life Science Innovation Award, Shulan Medical Science Young Scholar Award, China Science and Technology Young Scholar Award, etc.

Date and Time:7 April 2023

14:00-15:30 Academic Consultation

15:30-16:30 2C-Auditorium, East Complex Auditorium

Host: Dr.Di Chen

时隔三年

在大家的期盼和等待中

校园开放日重启啦！

诚挚邀请您

共赴浙江大学海宁国际校区

来一场关于春天和未来的约会

想实地感受国际化学习氛围？

想了解最新的招生政策？

想与教授面对面交谈？

想聆听院长高屋建瓴？

就在

2023年3月26日（周日）

浙江大学海宁国际校区

Breast Cancer Precision Medicine

Dr. Lim Yoon Pin

Ningbo Health and Industry Research Institute

Dr Lim was a professor at the National University of Singapore, founder and chief scientific officer of Oncotec, an in vitro diagnostics startup, before he was accorded the national high-level talent award by China. He joined the Ningbo health and industry research institute in Feb this year. 

Dr Lim owns 10 patents with 4 being licensed and/or commercialized. He published more than 60 peer reviewed papers and secured more than 10 million SGD as a PI and more than 30 million SGD as a co-PI. He is one of the global leaders in WBP2 oncogene research. He will share his scientific journey and findings of more than 10 years, starting from the discovery of a novel breast oncogene to its potential utility in early detection and precision medicine of cancer.

Date and Time: 22nd Mar. 2023

14:00-15:30 Academic Consultation

15:30-16:30 Room A203-1, ZJE building

Host: Ting Gang Chew

详细职位信息请见：

ZJE高层次人才招聘 | 国际化人文环境、多学科交叉平台等你加入

ZJE伙伴计划博士后招聘 | 国际化人文环境、多学科交叉平台等你加入

Chemical Biology of Biological Aggregates in Membraneless Organelles and the Stressed Proteome

Prof. Xin Zhang

School of Science, School of Life Sciences, Westlake Laboratory, Westlake University

Prof. Xin Zhang is the Professor of Chemistry and Cell Biology at the Westlake University, Hangzhou. Prior to joining the faculty at Westlake in 2021, Zhang was the Paul & Mildred Berg Early Career Professor and associate professor of chemistry and of biochemistry and molecular biology at the Pennsylvania State University. 

Prof. Zhang’s research is focused on the chemistry of biological aggregates formed by proteins and RNAs under physiological and pathological conditions. Zhang’s independent work has received multiple honors and awards, including Priestley Prize for undergraduate teaching in chemistry, Kavli Fellow of the National Academy of Sciences USA, CAPA Distinguished Junior Faculty Award, NSF CAREER award, NIGMS MIRA, Pew Scholar in the Biomedical Sciences, Scialog Fellowship, Sloan Research Fellowship, the Lloyd and Dottie Huck Early Career Award, the Burroughs Wellcome Fund Career Award at the Scientific Interface. 

Date and Time: 1st Mar. 2023

14:00-15:30 Academic Consultation

15:30-16:30 Room A203-1, ZJE building

Host:  Prof. Chaochen Wang

1.Talk title:

Nonadipogenic Role for Adipocyte Precursors

2.Speaker Name and Position and Institute:

Bo Shan (闪波)

Principal Investigator, Institute of Translational Medicine

Zhejiang University

3.Speaker introduction:

Dr. Bo Shan is a Principal Investigator at the Institute of Translational Medicine of Zhejiang University. The primary research focus of his group is to understand pathogenic mechanisms underlying metabolic diseases. Focusing on elucidating the mechanisms the mechanisms that elicit metabolic inflammation in adipose tissue and liver, his previous work has demonstrated the pathologic importance of metabolic tissue microenvironments as follows: 1) identifying the critical functions and underlying mechanisms of perivascular cells in initiating the formation of physiological and pathological microenvironment in adipose tissue; 2) illustrating the key role of macrophage ER homeostasis in regulating the pathological microenvironment in obese adipose tissue; 3) revealing the function of the ER stress sensor IRE1α in driving hepatic inflammation. The results of his work have been published in high-profile journals such as Cell Metabolism, Nature Metabolism, Nature Immunology, etc. Dr. Shan’s research is supported the National Natural Science Foundation and Ministry of Science and Technology of China.

4. Host

Prof Jian Liu

5. Date

2022/12/22 Wednesday 3：30pm-4:30pm

Building cell lineages in development and disease

Dr. Weike Pei

Westlake University

Dr. Weike Pei obtained his Ph.D. in Immunology at Heidelberg University in 2018. In graduate school, he worked with Dr. Hans-Reimer Rodewald on cell fate decision of hematopoietic stem cells. Following a one-year postdoctoral training at the German Cancer Research Center (DKFZ), he joined Dr. Vijay Kuchroo’s lab at Harvard Medical School/Brigham and Women’s Hospital as a Research Fellow, working on immune regulation and cancer immunotherapy. In 2022, Dr. Weike Pei joined Westlake University as an Assistant Professor at School of Life Sciences. His research is published in Nature, Cell Stem Cell, Nature Protocols, and other journals. Dr. Pei has received several awards including CRI Eugene V. Weissman Fellow, CRI Irvington Postdoctoral Fellowship and MIT Technology Review Innovators Under 35 (China).

Dr. Pei’s previous research was focused on the development and application of novel lineage tracing technologies for understanding cell fate decision. By integrating developmental biology, immunology, systems biology and synthetic biology, Pei lab is developing multi-dimensional single-cell lineage tracing technologies, which aims to study cell fate regulation at genetic, epigenetic, transcriptional, and spatial-temporal scales. Using novel single cell approaches, Pei lab is investigating the development and regeneration of the blood and immune system under physiological conditions and challenges such as cancer, infection and aging.

Date and Time: 7th Dec. 2022

14:00-15:30 Academic Consultation

15:30-16:30 Room A203-1, ZJE building

Host：Dr. Wanlu Liu

Mitochondria, autophagy, and neurodegeneration

Prof. Chao Tong

Life SciencesInstitute, Zhejiang University

Dr. Chao Tong’s major research interest is to dissect the molecular mechanisms underlying neurodegeneration diseases. Particularly, her lab is interested in how organelles such as mitochondria, autophagosomes, and lysosomes contribute to neuronal homeostasis. They aim to identify novel players and to define molecular pathways in neural maintenance by using Drosophila as a model system. They also applied these discoveries to the higher organisms. In this talk, she will introduce stories about Miga, a novel mitochondrial protein that is required for neuronal homeostasis. She will talk about how Miga regulates mitochondrial dynamics; how Miga functions as an ER-mitochondrial contact protein; and how Miga modulates autophagy processes. Dr. Chao Tong is supported by grants such as “The National Natural Science Foundation Outstanding Young Scholars Program” and “The National Natural Science Foundation, key program”. She serves as an associate editor of Science Bulletin and board member of Biophysical Society of China, membrane biology branch and mitochondrial biology branch.

Date and Time: 30th Nov. 2022

14:00-15:30 Academic Consultation

15:30-16:30 Meeting Room Online https://zju.webex.com/meet/zhihong

Host：Dr. Zhi Hong

Topic 

Epigenetic editing and therapeutic approaches to autism

Date and Time : 

22 November 2022, 10:00-11:00pm

Room A203-1, ZJE building 

Link:

Zoom:833 0831 3045

Passcode:aaaa1111

Speaker：

Prof. Rudolf Jaenisch

Founding Member, Whitehead Institute

Professor of Biology, MIT, Department of Biology

Host: Dr. Di Chen

Rudolf Jaenisch，美国科学院院士，麻省理工学院怀特黑德生物医学研究所教授，干细胞研究领域的权威人物，研究做出第一只转基因小鼠。他是怀特黑德研究所的创始人之一，曾经担任过国际干细胞学会的主席。其在一系列的领域做出了有影响的工作，包括基因敲除小鼠、表观遗传学研究、核移植、iPS等。

Jaenisch, a Whitehead Founding Member, focuses on understanding epigenetic regulation of gene expression. He is a pioneer in the study of cellular reprogramming, the process of converting adult cells into induced pluripotent stem (iPS) cells. 

Jaenisch’s lab was the first to create a transgenic animal model using SV40 and retroviruses. He has been the first to conduct an experiment showing that therapeutic cloning could correct genetic defects in mice. He is currently using patient-derived iPS cells to develop sophisticated models for the study of cancer, diabetes, and neurodegenerative disorders, including Alzheimer's disease and Parkinson's disease. Jaenisch is working with human stem cells to study disease risk factors. 

Jaenisch’s discoveries forever changed the landscape of how biological science is conducted. His methodological breakthroughs allow scientists, for the first time, to study human brain functions in normal and pathological conditions in its full complexity of all brain cell types. His stellar scientific acumen will be focused in partnership with Rick Young on condensate biology advancing research in cancer and neurodegenerative disease. 

Light sheet microscopy: push live imaging gently.

Dr. Min Guo

College of Optical Science and Engineering, ZJU

Dr. Min Guo is a tenure-track professor (100-Talent Investigator) at Zhejiang University. He received his Ph.D. degree in Instrument and Meter Engineering at Zhejiang University in 2016. He joined the National Institutes of Health as a Postdoc Fellow in 2016 and then as a Biomedical Scientist in 2019 before he returned to Zhejiang University in 2022. His research interests focus on high temporal-spatial resolution fluorescence microscopy including structured illumination microscopy, light sheet microscopy, and microscopic image analysis. He has developed several cutting-edge imaging techniques adopted in biomedical research by more than 20 labs across the world, and published ~ 20 papers in Journals such as Nature, Nature Biotechnology, Nature Methods etc. He also won the NIBIB’s Xiuwen Wang Memorial Award in 2019 and the Microscopy Today Innovation Award in 2020.

Date and Time: 16 Nov. 2022, 15:30-16:30

Room A203-1, ZJE building

Host：Dr. James Wang

Circular RNAs: subtypes, functions, and related mechanisms.

Prof. Ge Shan

School of Basic Medicine, University of Science and Technology of China (In transition). Run -Run Shaw Hospital, School of Medicine, Zhejiang University

Prof. Ge Shan have been focused on the study of noncoding RNAs for their regulatory roles in the flow of genetic information. His lab has identified new noncoding RNAs (e.g. MecciRNAs, EIciRNA, 5S-OT, ASAT siRNA, tiny RNA, p53R175H Aptamer RNA), and have revealed functions and novel functional mechanisms of these ncRNAs. Shan lab have explored methodologies of utilizing noncoding RNAs (e.g. p53R175H Aptamer RNA and human 5S-OT) to modulate the expression of genetic information. Dr. Ge Shan have published research articles as the senior corresponding author in journals such as Developmental Cell, Nature Structural & Molecular Biology, PNAS, Science Advances, and Nature Communications. These studies have been highlighted in Nature Reviews Molecular Cell Biology, Nature Reviews Genetics, Nature Reviews Microbiology, Science Editors’ Choice, etc. Dr. Ge Shan is supported by grants and professorship to top young Chinese scientists such as “The National Science Fund for Distinguished Young Scholars” and the National Leading Scientist of the “Ten Thousand Talent Program”.

Date and Time: 9 Nov. 2022, 15:30-16:30

Room A203-1, ZJE building

Host：Dr. Lingfeng Meng