On May 23, 2025, Nature Communications published online the latest research by Dr. Di Chen's group at the Zhejiang University-University of Edinburgh Institute and Dr. Matthew Brook's team at the University of Edinburgh on how RNA-binding proteins regulate the fate of human primordial germ cells. The study reveals that DND1 and NANOS3 are critical post-transcriptional repressors that function together to maintain the balance between somatic cells and germ cells.
https://www.nature.com/articles/s41467-025-57490-6#Sec10
Ziqing Wang and Honglin Yu, 2020 Ph.D. candidates at the Zhejiang University-University of Edinburgh Institute, are the co-first authors of this paper. Dr. Di Chen from the Zhejiang University-University of Edinburgh Institute and Dr. Matthew Brook from the University of Edinburgh are the co-corresponding authors of this study.
This study was supported by the National Natural Science Foundation of China, the Zhejiang Provincial Natural Science Foundation, and the Key R&D Program of the Ministry of Science and Technology. The authors also acknowledge the technical support from the Core Facilities at the Zhejiang University-University of Edinburgh Institute.
