On the afternoon of March 18, 2026, the 146th Biomed-X Research Seminar of ZJE was held in Room 2A-203, ZJE Building. At the invitation of Prof. Zhi Hong, Prof. Yongdeng Zhang — a Distinguished Researcher at the School of Life Sciences, Westlake University and Principal Investigator of the Super-Resolution Fluorescence Microscopy Laboratory — delivered an academic report titled “Elucidating Nanoscale Architectures and Dynamics in Cells and Tissue”.
Prof. Yongdeng Zhang has long focused on super-resolution fluorescence microscopy R&D and its biological applications, aiming to solve cellular microscopic observation challenges via technological innovation. In his report, he expounded on the development and breakthroughs of this technology around capturing cellular and tissue nanoscale architectures and their dynamics, noting that traditional microscopy’s resolution limit has bottlenecked life science research. Based on his team’s core achievements, he presented an expandable technical toolbox of two complementary super-resolution imaging technologies: (i) 4Pi single-molecule localization microscopy (4Pi-SIMFLUX, me4Pi-SMLM) with 2 nm isotropic localization precision for whole-cell molecular-scale analysis; (ii) 4Pi structured illumination microscopy (4Pi-SIM) for dual-color, time-lapse volumetric imaging, providing ~100 nm isotropic 3D resolution in living cells at 1 Hz. These technologies connect static molecular structures and living cell dynamics, enabling quantitative research unattainable with conventional fluorescence microscopy.
Faculty and students interacted actively during the event. Prof. Zhang answered all questions, helping attendees better understand the field’s frontiers, innovations, and application prospects.
As the 146th session of the Biomed-X Seminar series, this report underscores the institute's commitment to fostering high-level academic exchanges through its academic brand building efforts. The institute will continue to provide a platform for faculty and students to engage in cutting-edge scientific discussions.
