The Centre for Subcellular Biology and Signalling will focus on building a dynamic and comprehensive understanding on how organelles and other subcellular structures are organised and function in health and disease. In recent years have seen a tremendous increase in understanding cellular functions, in part due to the technical advances in super-resolution microscopy and genome editing. The centre will support research that systematically explores how the cell self-organizes to maintain cellular health using multidisciplinary approaches, including super-resolution imaging, mechanobiology, biomedical informatics, protein modelling, proteomics and molecular biology. We aim to inspire people push the boundaries of human knowledge of microscopic world, and fully devoted to connecting this knowledge to clinical need. Centre members have a shared research interests in function and interplay of various subcellular structures, in particular mitochondria, endoplasmic reticulum, cytoskeleton and the centrosome and have strong expertise in C. elegans as an in vivo model.
ZJE: Zhi Hong (Organelle crosstalk in nanoscale and contribution to cell homeostasis); Ting Gang Chew (Mechanobiology of the cytoskeleton); Chan Kuan Yoow (Centrosome signalling and cell cycle regulation); Lingfeng Meng (Signaling from DNA to organelles to Neuronal gap junction in organismal aging); Suhong Xu (Organelles in membrane repair); Mikael Bjorklund (Scaling of organelles with cell size for maintaining cellular homeostasis during aging)
Affiliated: Mike Shipston, Paula Brunton, Laura O’Hara, John Menzies, Joanne Murray, Michael Daw Partners: SAHZU, UoE and ZJU Medical Schools
Partners: SAHZU, UoE and ZJU Medical Schools
职占位称 : Centre for Cellular Biology and Signalling (CBS)
邮占位箱 : Zhi Hong and Mikael Bjorklund
研究方向 : The Centre for Subcellular Biology and Signalling will focus on building a dynamic and comprehensive understanding on how organelles and other subcellular structures are organised and function in health and disease. In recent years have seen a tremendous increase in understanding cellular functions, in part due to the technical advances in super-resolution microscopy and genome editing. The centre will support research that systematically explores how the cell self-organizes to maintain cellular health using multidisciplinary approaches, including super-resolution imaging, mechanobiology, biomedical informatics, protein modelling, proteomics and molecular biology. We aim to inspire people push the boundaries of human knowledge of microscopic world, and fully devoted to connecting this knowledge to clinical need. Centre members have a shared research interests in function and interplay of various subcellular structures, in particular mitochondria, endoplasmic reticulum, cytoskeleton and the centrosome and have strong expertise in C. elegans as an in vivo model.ZJE: Zhi Hong (Organelle crosstalk in nanoscale and contribution to cell homeostasis); Ting Gang Chew (Mechanobiology of the cytoskeleton); Chan Kuan Yoow (Centrosome signalling and cell cycle regulation); Lingfeng Meng (Signaling from DNA to organelles to Neuronal gap junction in organismal aging); Suhong Xu (Organelles in membrane repair); Mikael Bjorklund (Scaling of organelles with cell size for maintaining cellular homeostasis during aging) Affiliated: Mike Shipston, Paula Brunton, Laura O’Hara, John Menzies, Joanne Murray, Michael Daw Partners: SAHZU, UoE and ZJU Medical SchoolsPartners: SAHZU, UoE and ZJU Medical Schools
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